On July 27, 2026, a wholly owned subsidiary of VYNE Therapeutics Inc. ("VYNE") merged with and into the Issuer with the Issuer continuing as a wholly owned subsidiary of VYNE and the surviving corporation of the merger (the "Merger") under the name "Yarrow Bioscience Operating Company Corp." In connection with the Merger, OrbiMed Private Investments X, LP ("OPI X") received 233,019 Shares and pre-funded warrants ("Warrants") to purchase 4,084,827 Shares, and OrbiMed Genesis Master Fund, L.P. ("Genesis") received 33,287 Shares and Warrants to purchase 583,545 Shares. The Warrants contain an exercise limitation that prohibits the holder from exercising the Warrants to the extent that after giving effect to such issuance after exercise the holder would beneficially own in excess of 9.99% of the number of Shares outstanding immediately after giving effect to the issuance of the Shares issuable upon exercise of the Warrants (the "Blocker"). The exercise price of the Warrants is $0.0001 per Share.

In addition to the relationships between the Reporting Persons described in Items 2 and 5 above, OrbiMed GP is the general partner of GP LP pursuant to the terms of the limited partnership agreement of GP LP and GP LP is the general partner of OPI X. Pursuant to this agreement and relationship, GP LP has discretionary investment management authority with respect to the assets of OPI X. Such authority includes the power to vote and otherwise dispose of securities held by OPI X. The number of outstanding Shares of the Issuer attributable to OPI X is 233,019 Shares, which amount excludes Warrants to purchase 4,084,827 Shares that are not presently exercisable. OrbiMed GP and GP LP, pursuant to their authority under the limited partnership agreement of OPI X, may be considered to hold indirectly 233,019 Shares, which amount excludes the Warrants not presently exercisable. In addition to the relationships between the Reporting Persons described in Items 2 and 5 above, OrbiMed Genesis is the general partner of Genesis, pursuant to the terms of the limited partnership agreement of Genesis. Pursuant to this agreement and relationship, OrbiMed Genesis has discretionary investment management authority with respect to the assets of Genesis. Such authority includes the power to vote and otherwise dispose of securities held by Genesis. The number of outstanding Shares of the Issuer attributable to Genesis is 33,287 Shares, which amount excludes Warrants to purchase 583,545 Shares that are not presently exercisable. OrbiMed Genesis, pursuant to its authority under the limited partnership agreement of Genesis, may be considered to hold indirectly 33,287 Shares, which amount excludes the Warrants not presently exercisable. OrbiMed Advisors is the managing member of OrbiMed GP and OrbiMed Genesis, pursuant to the terms of the limited liability company agreements of OrbiMed GP and OrbiMed Genesis. Pursuant to these agreements and relationships, OrbiMed Advisors, OrbiMed GP, and GP LP have discretionary investment management authority with respect to the assets of OPI X. OrbiMed Advisors and OrbiMed Genesis have discretionary investment management authority with respect to the assets of Genesis. Such authority includes the power of GP LP to vote and otherwise dispose of securities held by OPI X and the power of OrbiMed Genesis to vote and otherwise dispose of the securities held by Genesis. The number of outstanding Shares attributable to OPI X is 233,019 Shares and the number of Shares attributed to Genesis is 33,287 Shares, which in each case, excludes the Warrants held by OPI X and Genesis that are not presently exercisable due to the Blocker. Mona Ashiya ("Ashiya"), a member of OrbiMed Advisors, is a member of the Board of Directors of the Issuer and, accordingly, OrbiMed Advisors may have the ability to affect and influence control of the Issuer. From time to time, Ashiya may receive stock options or other awards of equity-based compensation pursuant to the Issuer's compensation arrangements for non-employee directors. Pursuant to an agreement with OrbiMed Advisors, Ashiya is obligated to transfer any securities issued under any such stock options or other awards, or the economic benefit thereof, to OrbiMed Advisors, which will in turn ensure that such securities or economic benefits are provided to OPI X. Lock-Up Agreement Ashiya entered into a lock-up agreement (the "Lock-Up Agreement") pursuant to which, among other things, Ashiya agreed that she will not, during the period beginning on the closing of the Merger and ending 180 trading days thereafter (the "Lock-Up Period"), directly or indirectly (1) offer, pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase, lend, or otherwise transfer or dispose of, directly or indirectly, any Shares or any securities convertible into or exercisable or exchangeable for Shares owned or hereafter acquired by Ashiya or with respect to which Ashiya has or hereafter acquires the power of disposition (including, without limitation, Shares or such other securities which may be deemed to be beneficially owned (as such term is used in Rule 13d-3 of the Act and securities which may be issued upon exercise of a stock option or warrant by Ashiya or any other securities so owned convertible into or exercisable or exchangeable for Shares; (2) enter into any swap, short sale, hedge or other agreement that transfer, in whole or in part, any of the economic consequences of ownership of Shares, whether any such transaction described in clause (1) or this clause (2) is to be settled by delivery of Shares or such other securities, in cash or otherwise; (3) make any demand for, or exercise any right with respect to, the registration of any Shares or any security convertible into or exercisable or exchangeable for Shares; (4) except for any support agreement entered into as of the date hereof by Ashiya with VYNE and the Issuer, grant any proxies or powers of attorney with respect to any Shares, deposit any Shares into a voting trust or enter into a voting agreement or similar arrangement or commitment with respect to any Shares; or (5) publicly disclose the intention to do any of the foregoing. After the Lock-Up Period expires, Ashiya's Shares will be eligible for sale in the public market, subject to any applicable limitations under Rule 144 under the Securities Act, and other applicable U.S. securities laws. The foregoing description of the Lock-Up Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Lock-Up Agreement, which is filed as Exhibit 2 and incorporated herein by reference.

Exhibit Description 1. Joint Filing Agreement among OrbiMed Advisors LLC, OrbiMed Capital GP X LLC, OrbiMed Capital GP X LP, and OrbiMed Genesis GP LLC. 2. Form of Lock-Up Agreement (incorporated by reference to Exhibit A of Exhibit 10.3 to the Issuer's Current Report on Form 8-K (File No. 001-38356), filed with the SEC on July 27, 2026.